Cloprostenol
sodium is a synthetic analogue of dinoprost
(prostaglandin F2α).
It is used as a luteolytic agent in veterinary
medicine. Many dairy producers are using
cloprostenol to shorten cycle or induce cows to come
into heat. Until recently prostaglangins were only
used at herdcheck when the veterinarian palpated a
corpus luteum (CL) present on the ovary of a cow
open beyond the desired breeding time or 50 plus
days in milk. The prostaglandin products LutalyseR
(Pfizer), BovileneR (Syntex Animal Health) , and
EstrumateR (Schering-Plough) are equally effective
and all are highly luteolytic (will regress a CL)
when administered to cycling heifers which have a
functional CL (days 6 to 18 of a heat cycle).
Cloprostenol can help animal producers improve
production efficiency and economic returns.
Pharmacology
The injection of cloprostenol initiates luteolysis
with subsequent heat and ovulation. Following
intramuscular administration of 0.5mg and 10mg of
[14C]cloprostenol to cows urinary excretion
accounted for 58.2% and 56.3% of the dose
respectively. Unchanged cloprostenol and its
tetranor acid, probably formed by beta-oxidation,
were the major components identified in urine1
.
For use in beef cows
and heifers for estrous synchronization,
cloprostenol acts by rapidly regressing the CL on
the ovaries of cycling females in Days 6 to 16 of
their estrous cycles. The injection decreases the
function of the corpus
luteum,
which allows these females to return to estrus
within 2 to 5 days and synchronizes their estrous
cycles. Females in Days 17 to 20 will be in estrus
normally within 1 to 4 days and also will be
synchronized2.
Trials have shown
that normally 95% of animals will commence farrowing
within 36 hours of treatment. The majority of
animals can be expected to respond within the period
24(
±5)
hours following injection, except in those cases
where spontaneous farrowing is imminent3.
Applications
□
Treatment of suboestrus (or non-detected oestrus)
□
Induction of parturition4
□
Termination of abnormal and normal pregnancy5
□
Treatment of chronic bovine endometritis and ovarian
luteal cysts6
□
Estrous Synchronization for Dairy Cattle (BovileneR,
EstrumateR, LutalyseR etc.)
□
Farrowing Synchronization on commercial swine (PlanateR)
Proprietary Name
EstrumateR, PlanateR, BovileneR,
HeifexR, AzlumR
References
1. Bourne GR, et al., Biomed Mass
Spectrom 1980; 7(5):226-30
2. Cooper MJ, Acta Vet Scand Suppl,
1981; 77:171-9
3. Kostov L, et al., Vet Med Nauki,
1979; 16(3):63-70
4. Musah AI, et al., Biol Reprod
1987; 37(4):797-803
5. Van Leeuwen W, et al., Vet Q,
1983; 5(3):97-100
6. Sheldon IM. and Noakes DE., Vet Rec 1998;
142(21):575-9
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Categories
|
Products |
Applications |
|
Prostaglandins |
PG E1
|
Treatment of
cardiovascular diseases |
|
PG E2
|
Labor induction
|
|
PG I2
|
Treatment of primary
pulmonary hypertension
|
|
Misoprostol/
Misoprostol HPMC |
Treatment of peptic
and duodenal ulcers caused by the use of NSAIDs
|
|
Latanoprost |
Treatment of Glaucoma |
|
Bimatoprost |
Treatment of Glaucoma |
|
Travoprost |
Treatment of Glaucoma |
|
Cloprostenol Sodium
(racemate)/(+) |
Labor induction and
breeding management in veterinary |
|
Cardiovascular API |
Felodipine
|
Anti-hypertensive
and treatment of congestive heart failure
|